| Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | |
|---|---|---|---|---|---|---|---|
| 1 | Byrnes | A | Kone, Nellie | Weatherly, Nyasia | Grayson, Ly'rique | Washington, Amerie | 4:12.00 |
| 2 | Dorman | A | Norman, McKayla | Brownlee, Rodnayzia | Jones, Journe | Freeman, Jayonce | 4:16.05 |
| 3 | Spartanburg | A | Cohen, Shakya | Atchison, London | Blackley, Currin | Hollman, Anaya | 4:18.00 |
| 4 | Chesnee | A | BLAIR, KYHMIA | Besaw, Jakeo | Jones, Tanner | Tracy, Taylor | 4:20.00 |
| 5 | Woodruff | A | Vasquez, Alicia | Scott, Taliyah | Sandoval, Kelly | thompson, katherine | 4:23.00 |
| 6 | Chapman | A | Addington, Polly | Conner, Victoria | Hampton, Nevaeh | Terrell, Lailonie | 4:30.00 |
| 7 | Carolina Homeschool Cougars | A | Poole, Caroline | Wilson, Cindy | Hilt, Shelby | Baird, Maura | 4:35.03 |
| 8 | Broome | A | Cristales, Crystal | Fowler, Aaliyah | Price, Logan | Lyles, Brazyah | 4:44.00 |