| Lane | # | Athlete | Team | Seed |
|---|---|---|---|---|
| 1 | 385 | BOYD, Natilee | Strom Thurmond | 3:03.53 |
| 2 | 111 | KUPCHINSKY, Emmy | Lexington HS | 3:04.47 |
| 3 | 396 | DAVILA ONTIVEROS, Maria | Saluda | 3:06.74 |
| 4 | 431 | STONE, Aubrey | Saluda | 3:07.30 |
| 5 | 402 | NORRIS, Amari | Saluda | 3:07.97 |
| 6 | 416 | TUCKER, Jaemera | Saluda | 3:11.50 |
| 7 | 196 | FERNANDEZ, Lillian | American Leadership Academy | 3:12.00 |
| 8 | 379 | SCOTT, Asharwie | Strom Thurmond | 3:14.03 |
| 9 | 378 | GORDON, Alaiyah | Strom Thurmond | 3:30.82 |
| 10 | 21 | HARRIS, Jasmin | Columbia | 3:33.12 |
| 11 | 24 | PRESTON, Paris | Columbia | 3:56.70 |
| 12 | 49 | HUNTER-PERSON, Toyaniyah | Columbia | 3:59.10 |
| 13 | 187 | LLOYD-RIVERS, Jordyn | American Leadership Academy | 3:59.41 |
| 14 | 347 | BROWN, Nichole | Strom Thurmond | 4:12.13 |
| 15 | 343 | BOYD, Ashlee | Strom Thurmond | NT |
| Lane | # | Athlete | Team | Seed |
|---|---|---|---|---|
| 1 | 119 | MILES, Kendra | Lexington HS | 2:16.77 |
| 2 | 232 | BONAVILLA, Jacqueline | Chapin | 2:18.93 |
| 3 | 273 | HOUMIEL, Addison | Chapin | 2:21.12 |
| 4 | 154 | DAVIS, Savannah | River Bluff | 2:21.47 |
| 5 | 213 | TREVETT, Reagan | Chapin | 2:23.29 |
| 6 | 108 | KRAMER, Ava | Lexington HS | 2:23.57 |
| 7 | 262 | HOLMAN, Lilly | Chapin | 2:25.60 |
| 8 | 277 | BONAVILLA, Bella | Chapin | 2:31.80 |
| 9 | 99 | KEYTON, Kennedy | Lexington HS | 2:34.91 |
| 10 | 72 | MILLER, Hayley | Lexington HS | 2:39.89 |
| 11 | 233 | GUMMERE, Anne Marie | Chapin | 2:41.15 |
| 12 | 132 | BRADBERRY, Emma | Lexington HS | 2:46.99 |
| 13 | 332 | ANTLEY, Claire | Chapin | 2:49.98 |
| 14 | 377 | JONES, Amiah | Strom Thurmond | 2:50.36 |
| 15 | 411 | PEDROZA, Kate | Saluda | 2:56.80 |
| 16 | 437 | ETHEREDGE, Eleacia | Saluda | 2:58.34 |