| Lane | Athlete | Team | Seed |
|---|---|---|---|
| 1 | PERRY, Laura | Philip Simmons | 5:16.69 |
| 2 | TAYLOR, Flynn | Philip Simmons | 5:21.58 |
| 3 | MALLEK, Avah | Philip Simmons | 5:27.49 |
| 4 | ANGLE, Cate | Academic Magnet | 5:32.65 |
| 5 | WININGER, Stella | Philip Simmons | 5:33.69 |
| 6 | HANNA, Taryn | Hampton County High School | 5:49.79 |
| 7 | RINEHART, Taylor | Woodland | 5:52.04 |
| 8 | LEE, Shae | East Clarendon | 5:55.26 |
| 9 | LOWE, Kinsley | Chesterfield | 5:58.34 |
| 10 | HARPER, Lucy | Academic Magnet | 6:01.20 |
| 11 | LOWE, Amrie | Chesterfield | 6:01.66 |
| 12 | TUCKER, Gracen | Central | 6:03.58 |
| 13 | LOWE, Bria | Chesterfield | 6:03.67 |
| 14 | MCCRANN, Anna | Academic Magnet | 6:20.09 |
| 15 | OWENS, Kira | East Clarendon | 6:20.57 |
| 16 | LEPISTO, Kaylee | Hampton County High School | 6:52.51 |
| 17 | WALLS, Shaelynn | Andrew Jackson | 6:56.40 |
| 18 | BURGESS, Sha'nyiah | Manning | 7:07.89 |
| 19 | STOGNER, Drake | Buford | 7:15.35 |