| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | NIMMO, Raynie | Chapin | 5:20.97 | |
| 2 | BONAVILLA, Bella | Chapin | 5:31.33 | |
| 3 | KAPLAN, Suri | Chapin | 5:59.85 | |
| 4 | JENKINS, Hope | Chapin | 6:04.58 | |
| 5 | BROCK, Faith | Chapin | 6:04.93 | |
| 6 | CAREY, Ava | Irmo | 6:06.98 | |
| 7 | JAMES, Samantha | Chapin | 6:12.89 | |
| 8 | ROGERS, Tessa | Chapin | 6:19.23 | |
| 9 | STALLWORTH, Vivian | Chapin | 6:20.85 | |
| 10 | PETERS, Georgia | Chapin | 6:30.22 | |
| 11 | DAVIS, Elise | Chapin | 6:37.37 | |
| 12 | MAJOR, Savannah | Chapin | 6:37.65 | |
| 13 | HOLMAN, Evelyn | Chapin | 6:44.35 | |
| 14 | FRUEAUF, Savannah | Chapin | 6:46.97 | |
| 15 | LAND, Eleanor | Chapin | 6:48.74 | |
| 16 | ERNST, Evelyn | Irmo | 6:53.00 | |
| 17 | ANDERSON, Clare | Chapin | 6:54.12 |
| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | DIMAGGIO, Abigail | Chapin | 6:56.58 | |
| 2 | MCCANTS, Korlie | Airport | 7:00.45 | SCHSL 4A - District 3 |
| 3 | TRAVIS, Adalie | Chapin | 7:10.58 | |
| 4 | THORNTON, Ayana | Airport | 7:14.42 | River Bluff Frosh/Soph Invitatio |
| 5 | ERNST, Amy | Irmo | 7:22.98 | |
| 6 | CHINN, Maliyah | Strom Thurmond | 7:25.81 | |
| 7 | COOPER, Jessica | Strom Thurmond | 7:41.23 | |
| 8 | WISE, Allie | Strom Thurmond | 7:53.22 | |
| 9 | PENDERGRASS, Janaiya | C.A. Johnson | 7:53.52 | |
| 10 | BOYD, Ashlee | Strom Thurmond | 8:46.58 | |
| 11 | LUCKEY, Kamiah | Airport | NT | |
| 12 | ARAGON, Makaylah | Strom Thurmond | NT | |
| 13 | ARMOUR, Ariana | Airport | NT | |
| 14 | HAMIN, Anyiah | C.A. Johnson | NT | |
| 15 | ANDRES LORENZO, Melina | Airport | NT | |
| 16 | SCOTT, Asharwie | Strom Thurmond | NT | |
| 17 | SMITH, Za'Niyah | Airport | NT | |
| 18 | UTSEY, Ja'Keria | Airport | NT |