| Lane | Athlete | Team | Seed |
|---|---|---|---|
| 1 | MAY, Lilah | Philip Simmons | 5:43.15 |
| 2 | ORTH, Elizabeth | Cane Bay | 5:46.29 |
| 3 | DELAMIELLEURE, Lexi | Hanahan | 5:50.65 |
| 4 | BOYLES, Sara Belle | Palmetto Christian Academy | 5:52.35 |
| 5 | CINNAMON, Lacie | Summerville | 5:53.40 |
| 6 | TIMMONS, Lydia | North Charleston | 5:58.92 |
| 7 | HURLEY, Josie | Palmetto Christian Academy | 6:01.50 |
| 8 | JULIUS, Farrell | Lucy Beckham | 6:02.16 |
| 9 | ATKINSON, Taylor | Hanahan | 6:12.51 |
| 10 | ARRANTS, Cate | Academic Magnet | 6:14.99 |
| 11 | PENICK, Abigail | Ashley Ridge | 6:18.50 |
| 12 | SANTOS, Amelia | Cane Bay | 6:20.00 |
| 13 | WITHERS, Anne | Stratford | 6:23.16 |
| 14 | GRIZZLE, Catherine | Bishop England | 6:25.91 |
| 15 | WOJTON, Hazel | St. Johns | 7:31.56 |
| 16 | GARNETT, Nancy | Stall | 7:42.82 |
| 17 | CHRISTIANSEN, Olivia | Woodland | 7:50.83 |
| 18 | TONEY, Kalissa | Stall | 7:55.30 |
| Lane | Athlete | Team | Seed |
|---|---|---|---|
| 1 | VROON, Hannah | James Island | 4:58.24 |
| 2 | BRAHIM, Nora | Bishop England | 5:11.68 |
| 3 | TIMMONS, Ellie | North Charleston | 5:13.00 |
| 4 | STUDLEY, Tess | Fort Dorchester | 5:24.50 |
| 5 | HOLLISTER, Anna | Academic Magnet | 5:25.64 |
| 6 | PERRY, Laura | Philip Simmons | 5:27.58 |
| 7 | PACZKOWSKI, Kate | Wando | 5:27.60 |
| 8 | MARTENS, Rowyn | Wando | 5:27.94 |
| 9 | BORG, Kirra | James Island | 5:28.11 |
| 10 | DOONEY, Brianna | Summerville | 5:28.17 |
| 11 | HENDERSON, Kallie | Ashley Ridge | 5:29.31 |
| 12 | BLITCH, Ellie | First Baptist | 5:29.51 |
| 13 | STROBLE, Ivy | St. Johns | 5:31.36 |
| 14 | RUNION, Cloe | Stratford | 5:31.94 |
| 15 | MARION, Bryce | Porter Gaud | 5:35.56 |
| 16 | STUDLEY, Megan | Fort Dorchester | 5:36.18 |
| 17 | KOWALSKI, Mallory | Porter Gaud | 5:36.96 |
| 18 | MCINNES, Ali | Lucy Beckham | 5:37.40 |