| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | SCHAAF, Alexa | Palmetto Christian Academy | 6:00.00 | Unverified: |
| 2 | WILLIAMS, Sadie | Ashley Ridge | 6:04.00 | Unverified: |
| 3 | RABON, Lexi | Woodland | 6:05.81 | Verified |
| 4 | WARD, Grace | Philip Simmons | 6:09.81 | Verified |
| 5 | CONVILLE, Alexandra | Hanahan | 6:12.18 | Verified |
| 6 | CALDWELL, Olivia | Ashley Ridge | 7:09.00 | Unverified: |
| 7 | O'NEAL, Avery | Ashley Ridge | 7:20.00 | Unverified: |
| 8 | BARRIENTOS, Carol | Bluffton | NT | Unverified: |
| 9 | BELL, Breanna | Manning | NT | Unverified: |
| 10 | BLANCO, Johania | Bluffton | NT | Unverified: |
| 11 | CASTRO, Keidy | Bluffton | NT | Unverified: |
| 12 | DAVIS, Brooke | Allendale-Fairfax | NT | Unverified: |
| 13 | ELLIS, Ashley | Manning | NT | Unverified: |
| 14 | WILLIAMS, Aniyah | Whale Branch Early College | NT | Unverified: |
| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | MEYERS, Hailey | Philip Simmons | 5:16.76 | Verified |
| 2 | JOHNSON, Hanna | Hanahan | 5:28.77 | Verified |
| 3 | LOFTUS, Anna Margaret | Waccamaw | 5:31.92 | Verified |
| 4 | LEONE, Gia | Waccamaw | 5:35.00 | Unverified: |
| 5 | MAY, Josie | Philip Simmons | 5:35.00 | Unverified: |
| 6 | CAVE, Mae | Palmetto Christian Academy | 5:38.00 | Verified |
| 7 | STUDLEY, Megan | Fort Dorchester | 5:43.06 | Verified |
| 8 | BOWERS, Becca | Palmetto Christian Academy | 5:43.23 | Verified |
| 9 | ALTMAN, Grayson | Colleton County | 5:44.34 | Verified |
| 10 | FRANCKE, Alice | Waccamaw | 5:47.10 | Verified |
| 11 | STUDLEY, Tess | Fort Dorchester | 5:48.58 | Verified |
| 12 | FUTRELL, Kylie | Hanahan | 5:48.98 | Verified |
| 13 | ARMES, Margaret | Battery Creek | 6:00.00 | Unverified: |