| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 3 | Elkhart Christian | A | Manriquez | Meyer | Jones | Miller | 4:40.00 | |
| 4 | Ft. Wayne Blackhawk Christian | A | Barchak | Suvar | Jackson | Brewer | 4:31.66 | ECA Invite |
| 5 | Concord | A | Mashala | Anglemyer | Brosamer | Haggan | 4:30.00 | |
| 6 | Jimtown | A | Bennett | Lopez-Villafane | Ruffin | McKenzie | 4:30.25 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 3 | Leo | A | Bultemeier | Baker | Detmers | Sauter | 4:25.69 | |
| 4 | Fairfield | A | Holsopple | Miller | Walter | Hinkle | 4:24.00 | |
| 5 | Ft. Wayne Canterbury | A | Chaille | Brooks | Kim | Varga | 4:18.66 | IHSAA Regional 3 (Girls) |
| 6 | Angola | A | Elsworth | Ross | Newhard | Knox | 4:21.87 | 2025 NECC Championship Meet |