| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Elkhart | A | Richter | Kale | Rosales | Malloy | 8:35.02 | 2022 Goshen Relays - Boys Class A |
| 2 | South Bend Riley | A | Rivas | Wittrock | Gaddey | Caparell | 8:36.00 | |
| 3 | Trinity (Greenlawn) | A | Schwenkler | Kwilinski | Seachris | Lee | NT | |
| 4 | South Bend St. Joseph | A | Miller | Russo | Moran | Polaniecki | 8:50.00 | |
| 5 | Huntington North | A | Lisinicchia | Stevens | Boxell | Eidson | 9:10.00 | |
| 6 | Elkhart | B | Aguilar | Aguilar | Swinehart | Mehl | 9:30.02 | |
| 7 | Northridge | A | Spicher | Miller | Keyser | Miller | 8:30.00 | |
| 8 | Chesterton | B | Wilgocki | McGrogan | Morgan | Arlington | 9:30.00 | |
| 9 | South Bend St. Joseph | B | Risk | Vogel | Robles | Elick | 9:30.00 | |
| 10 | Angola | A | Klink | Hoover | Hinkley | Cooke | 9:00.00 | |
| 11 | South Bend Adams | A | Keen | Howk | Geels | Tinoco | 9:40.00 | |
| 12 | Chesterton | A | Tuck | Berger | Sierazy | O'Connor | 8:41.14 | Bulldog Invite |