| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | South Bend St. Joseph | A | Sparke | Suggs | Ortiz | Miller | 1:36.00 | |
| 2 | South Bend Riley | A | Avila | Simpson | Ford | Chinn | 1:35.87 | 2022 Goshen Relays - Boys Class A |
| 3 | Chesterton | A | Fleming | Throw | Barnewall | Resto | 1:33.00 | |
| 4 | LaPorte | A | Henriot | McNeal | Anderson | Williams | 1:33.30 | Hoosier State Relays Finals (Large Schools) |
| 5 | South Bend Adams | A | Brissau | Blount | Tootoo | Lemay | 1:36.00 | |
| 6 | South Bend Riley | B | Jones | Chibambo | Conley | Witz | 1:36.60 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Fairfield | A | Metzger | Henry | Herschberger | Garcia | 1:40.00 | |
| 2 | Lakeland | A | Thompson | Troyer | Lawrence | Malaivanh | 1:39.00 | |
| 3 | Elkhart | A | Dow | Munson | Newson | Huckleberry | 1:37.15 | Trine HSR Qualifier #3 |
| 4 | LaPorte | B | Pham | Henckel | Long | Clay | 1:38.00 | |
| 5 | Huntington North | A | Wagner | Christiansen | Brooks | Blair | 1:39.75 | Trine HSR Qualifier #1 |
| 6 | Chesterton | B | Powell | Woods | Vaughn | Lemus | 1:40.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Huntington North | B | Mautz | Booher | Kalhoefer | Stahl | 1:45.00 | |
| 2 | Plymouth | A | Druzbicki | Graham | Mackey | Stiger | 1:43.03 | 2022 NWI Championships |
| 3 | South Bend St. Joseph | B | Harshman | Lopez | Rutland | Kimbrough | 1:42.00 | |
| 4 | Lakeland | B | Bell | Colon | Larimer | Schiffli | 1:42.00 | |
| 5 | Northridge | A | Bontrager | Mathias | 1:45.00 | |||
| 6 | Angola | A | Morvilius | Newcomer | Thomas | Miller | 1:45.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Northridge | B | Bauta | Snider | Gutierrez | Woodward | 1:55.00 | |
| 2 | Fairfield | B | Herr | Geiger | Cripe | Miller | 1:50.00 | |
| 3 | Elkhart | B | Leonard | Ryall | Cole | Newson | 1:45.98 | |
| 4 | Angola | B | Carminati | Taylor | Koch | Phillips | 1:50.00 | |
| 5 | South Bend Clay | A | Jones | Jones | Taylor | Barber | NT | 2022 West Lafayette HSR Qualif |