| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Angola | B | Fletcher | Burk | Sutton | Davenport | 4:25.00 | |
| 2 | Chesterton | A | Bamber | Raffin | Morris | Hurst | 4:20.00 | |
| 3 | Angola | A | Gillen | Davenport | Thomas | Underwood-Sanders | 4:10.00 | |
| 4 | South Bend Adams | A | Soens | Cruz | Douglas | Thomas | 4:10.00 | |
| 5 | Concord | A | Latif | Fisher | McKain | DeFreese | 4:20.50 | |
| 6 | Chesterton | B | Raffin | Beumer | Pulsoni | Hardsock | 4:30.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Elkhart | B | Addington | Becraft | Dikes | Higgins | 4:51.94 | Trine HSR Qualifier #3 |
| 2 | Concord | B | Myers | Campanello | Jackson | Jones-Perry | 4:35.50 | |
| 3 | Mishawaka | A | Parks | Shelton | Naragon | Smith | 4:32.46 | Trine HSR Qualifier #1 |
| 4 | Plymouth | A | Gurtner | Jones | Joseph | Ameling | 4:35.00 | |
| 5 | LaPorte | A | Conlin | Spain | Hertges | Conner | 4:38.64 | 2022 NWI Championships |
| 6 | Elkhart | A | Williams | Brown | VanPelt | Aguirre | 4:51.94 | Trine HSR Qualifier #3 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Lakeland | B | Sanchez | Granados | Alleshouse | Gyovai | 5:15.00 | |
| 2 | Fairfield | A | Troyer | Miller | Miller | Culp | 5:00.00 | |
| 3 | Lakeland | A | Wallace | Schiffli | Brown | Ryan | 4:56.57 | Trine HSR Qualifier #3 |
| 4 | Trinity (Greenlawn) | A | Preuss | Scroope | Tormey | Pingel | NT | 2022 NWI Championships |
| 5 | Fairfield | B | McCauley | Bechtel | Kuhn | Lambright | 5:05.00 | |
| 6 | South Bend St. Joseph | A | Prokop | Frick | Ritschard | Hopkins | NT |