| ! | BHWC HS | 4:17.99 | Dean, Fran, Allen, Johnson | Lancaster | 1/26/2025 |
| @ | HS Last Chance | 4:28.24 | Swallow, Jewett, Barry, Meeker | Col. St. Francis DeSales | 2/19/2023 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Shenandoah | A | NT | ||||
| 2 | Huntington | A | Lute | Magill | Richards | Jenkins | NT |
| 3 | Martins Ferry | A | Williams | Call | Brandon | Williams | 4:30.89 |
| 4 | Unioto | A | West | Lloyd | McDonald | Link | 4:27.00 |
| 5 | Thom. Worthington | A | Rivers | Turner | Raymond | Perkins | 4:19.0h |
| 6 | John Glenn | A | 4:25.00 |