| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Clover | A | DeJacimo | Silmon | Grayson | Hodnett | NT |
| 3 | Indian Land | A | Morris | Conner | Wilson | Arnold | 3:58.00 |
| 4 | Nation Ford | A | Dixon | Johnson | Hailstock | Hunter | 3:28.0h |
| 5 | Catawba Ridge HS | A | Brown | McKinney | Keppery | Mack | 3:44.49 |
| 6 | South Pointe | A | Douglas | Ginn | Moton | Blanchard | 4:40.27 |
| 7 | Rock Hill | A | Cintron | Roy | Tucker | Strayhorn | NT |
| 8 | Northwestern | A | Jones | Orr | Smith | Stradford | NT |