| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Catawba Ridge HS | A | Jones | Kowalski | Myatt | Sivil | 3:37.07 |
| 2 | Nation Ford | A | Allen | Pickett | Saddler | Richardson | DNS |
| 3 | Rock Hill | A | Pitters | Moore | Cintron | Gadson | DNS |
| 4 | Fort Mill | A | AMICO | Dubak | Gremillion | Mccants | 3:23.01 |
| 5 | Indian Land | A | Ledford | Davis | Foster | Daniels | 3:25.07 |
| 6 | Clover | A | Kozel | Kucharczak | Jones | Waid | 3:29.03 |
| 7 | Northwestern | A | Morton | Bybee | Williamson | Thomas | 3:31.40 |