| Lane | Athlete | Team | Seed |
|---|---|---|---|
| 1 | CAMPBELL, Isaac | Fort Mill | 4:22.71 |
| 2 | HALEY, Hudson | Fort Mill | 4:30.10 |
| 3 | LECKRONE, Finn | Fort Mill | 4:32.84 |
| 4 | BOHLEN, Alex | Clover | 4:36.0h |
| 5 | PADDYFOTE, Nicholas | Paddyfote Learning Center HS | 4:36.38 |
| 6 | DEMMERLE, Connor | Fort Mill | 4:37.28 |
| 7 | LARNER, Zack | Fort Mill | 4:39.95 |
| 8 | WARE, Owen | Fort Mill | 4:40.51 |
| 9 | POGALZ, Greyson | Fort Mill | 4:46.36 |
| 10 | SOLOMON, Ethan | Clover | 4:48.0h |
| 11 | HENSLEY, Chase | Clover | 4:53.0h |
| 12 | KOHR, Christopher | Fort Mill | 4:54.15 |
| 13 | MARSH, Jackson | Fort Mill | 4:54.17 |
| 14 | MADEJ, Ben | Fort Mill | 4:56.75 |
| 15 | PARKER, Reeves | Fort Mill | 5:00.37 |
| 16 | REBMAN, Chase | Fort Mill | 5:21.24 |
| 17 | CULLEN, Preston | Fort Mill | 5:24.47 |
| 18 | MURRI, John | Fort Mill | 5:35.40 |
| 19 | JONES, Carter | Fort Mill | 5:39.53 |
| 20 | SCHUHMACHER, Nicolas | Fort Mill | 5:50.09 |
| 21 | SCHWERDTFEGER, Noah | Fort Mill | 5:57.50 |
| 22 | PAYNE, Jacob | Fort Mill | 6:01.96 |
| 23 | JOHNSON, Zachary | Fort Mill | 6:02.17 |
| 24 | PYRC, Owen | Fort Mill | 6:13.17 |
| 25 | SNYDER, Lucas | Fort Mill | NT |
| 26 | WIGGINTON, Aidan | Fort Mill | NT |