| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | BUDHRAM, Daniel | Hartsville | 4:50.72 | SCHSL 4A - Region 6 |
| 2 | ROGERS, Hampton | Dreher | 4:53.27 | SCHSL 3A - Lower State |
| 3 | ROTH, Micah | Dreher | 4:59.87 | SCHSL 3A - Lower State |
| 4 | BURNELL, Justin | Lower Richland | 5:01.74 | SCHSL 3A - Lower State |
| 5 | HALLE, Westin | Lugoff Elgin | 5:04.74 | Speed Demon Showcase 2025 |
| 6 | DENNIS, Blake | Lugoff Elgin | 5:05.59 | SCHSL 4A - Region 5 |
| 7 | INGRAM, Christian | Sumter | 5:05.73 | Bob Jenkins Coaches Classic Trac |
| 8 | POUGE, Jahiem | Crestwood | 5:10.26 | SCHSL 3A - Lower State |
| 9 | ESAW, Daelyn | Wilson | 5:20.00 | |
| 10 | SALOIS, Caleb | South Florence | 5:25.00 | Last Chance Trojan Classic |
| 11 | HOSTUTLER, Coen | Lugoff Elgin | 5:25.13 | SCHSL 4A - Region 5 |
| 12 | BENNETT, Fra'Jon | Scott's Branch | 5:28.50 | The Wood Lowcountry Invitational |
| 13 | HUGHES, Elijah | Dreher | 5:29.57 | Westwood Home Meet |
| 14 | LITTLE, Maze | Darlington | 5:31.42 | Darlington Meet 1 |
| 15 | HINSON, Reid | Lugoff Elgin | 5:32.15 | Speed Demon Showcase 2025 |
| 16 | MULBAH, Eric | Blackville-Hilda | 5:32.32 | SCHSL 1A - Upper-State |
| 17 | FAMUYIDE, Adesina | Richland Northeast | 5:33.46 | SCHSL 4A - Region 5 |
| 18 | DANIELS, Tashawn | Lugoff Elgin | 5:33.94 | Speed Demon Showcase 2025 |
| 19 | TALBERT, Hayden | Lugoff Elgin | 5:34.25 | Speed Demon Showcase 2025 |
| 20 | SMITH, Ryder | Andrew Jackson | 5:35.15 | North Central Home Meet |
| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | JOHNSON, Trenden | Crestwood | 5:35.98 | Wilson Hall Meet 4 |
| 2 | PARKER, Malik | Wilson | 5:36.44 | SCHSL 4A - Region 6 |
| 3 | MORGAN, Micah | Hartsville | 5:38.23 | West Florence Meet 1 |
| 4 | KIRVEN, Allen | South Florence | 5:39.49 | SCHSL 4A - Region 6 |
| 5 | JOHNSONN, Ahmad | Wilson | 5:43.94 | SCHSL 4A - Region 6 |
| 6 | BRYANT, Andrew | Lakewood | 5:44.26 | SCHSL 3A - Region 6 |
| 7 | KRIVEJKO, Nathaniel | Sumter | 5:48.49 | Diamond Hornets Invitational |
| 8 | THOMPSON, Nathan | Darlington | 5:55.65 | SCHSL 3A - Region 6 |
| 9 | ALEXANDER, Dayton | South Florence | 5:58.04 | North Myrtle Beach Home Meet #1 |
| 10 | HOWELL, Hayden | South Florence | 5:59.57 | North Myrtle Beach Home Meet #1 |
| 11 | BOLTON, Conner | Wilson | 6:03.37 | Wilson Tiger's Invitational |
| 12 | BENNETT, Ethan | Hartsville | 6:06.01 | Wilson Tiger's Invitational |
| 13 | TRUETT, John Ryan | Hartsville | 6:06.92 | West Florence Meet 1 |
| 14 | LAWING, Roman | Camden | 6:08.25 | Camden Bulldog Invitational |
| 15 | RATIU, Alexandru | Hartsville | 6:10.0h | |
| 16 | LEMMONDS, Ryan | Camden | 6:11.03 | Camden Home Meet #2 |
| 17 | COX, Malachi | Camden | 6:20.13 | Camden Home Meet #2 |
| 18 | BROWN, Braylon | East Clarendon | 6:23.26 | Bulldog Invitational |
| 19 | WISE, Kaylon | Lakewood | 6:32.37 | Diamond Hornets Invitational |
| 20 | BROOKS, Jarius | Darlington | 6:39.17 | Wilson Home Meet #1 |
| 21 | DAVIS, Christian | Crestwood | NT |
| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | MOLINA, Misael | East Clarendon | 7:07.14 | SCHSL 1A - Region 5 |
| 2 | BENNETT, Zane | Hartsville | 7:12.88 | West Florence Meet 1 |
| 3 | BATES, Bentley | Camden | NT | |
| 4 | BROWN, Travarius | Blackville-Hilda | NT | |
| 5 | CONWAY, Kaleb | Sumter | NT | |
| 6 | DEMMA, Lincoln | Camden | NT | |
| 7 | HODGES, Landon | South Florence | NT | |
| 8 | HOLLIS, Xavier | Columbia | NT | |
| 9 | JACOBS, Eric | Darlington | NT | |
| 10 | JOHNSON, Jahiem | Blackville-Hilda | NT | |
| 11 | KELLAM, Ja'von | South Florence | NT | |
| 12 | LONEY, Kanaii | Crestwood | NT | |
| 13 | LOWE, Kelvonta | Darlington | NT | |
| 14 | MARKEVICHUS, Yaraslau | Scott's Branch | NT | |
| 15 | MAYS, Grover | Blackville-Hilda | NT | |
| 16 | RAGIN, Steven | Scott's Branch | NT | |
| 17 | ROBINSON, Jett | East Clarendon | NT | |
| 18 | SANTIAGO-MARTINEZ, Jose | Crestwood | NT | |
| 19 | WEST, Kevin | Camden | NT | |
| 20 | WITKINS, Jordan | Crestwood | NT | |
| 21 | EPPS, Kenneth | Crestwood | NT |