| # | Spartanburg County | 8:04.04 | Dorman | Dorman | 4/26/2022 |
| Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | |
|---|---|---|---|---|---|---|---|
| 1 | Dorman | A | Bryant | Cleland | Edwards | Workman | 8:07.23 |
| 2 | Spartanburg | A | Alchab | Atance | Nunes | Eaton | 8:11.52 |
| 3 | Chapman | A | Wines | Wheeler | Walters | Chambers | 8:35.70 |
| 4 | Byrnes | A | Eitel | Palmer | Schrock | Cummings | 8:39.93 |
| 5 | Landrum | A | Davis | Hall | Dill | Donaldson | 8:55.29 |
| 6 | Chesnee | A | Hill | Hamilton | Ocampo-Rios | Jones | 9:10.00 |
| 7 | Boiling Springs | A | Glover | Adams | Thomas | Sapp | 9:10.79 |
| 8 | Broome | A | O'Dell | Odom | Vrooman | Greene | 9:14.19 |
| 9 | Woodruff | A | Westmoreland | Johnson | Vaughn | Craig | 9:21.98 |
| 10 | Carolina Homeschool | A | Sarazen | Kendrick | Strange | Gunter | 9:25.00 |
| 11 | High Point Academy | A | 11:45.57 |