| # | Spartanburg County | 48.50 | Spartanburg | Spartanburg | 4/1/2005 |
| Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | |
|---|---|---|---|---|---|---|---|
| 1 | Byrnes | A | Wright | Rice | Griffin | Miller | 49.08 |
| 2 | Boiling Springs | A | Grate | Garner | Dawkins | Watson | 49.65 |
| 3 | Spartanburg | A | Means-Boyd | Miller | Ferguson | Webster | 50.96 |
| 4 | Dorman | A | Deck | Littlejohn | Boyce-Martin | McKelvey | 51.05 |
| 5 | Broome | A | 51.20 | ||||
| 6 | Landrum | A | Clayton | Haro | Higgins | Fincher | 53.29 |
| 7 | Chapman | A | Johnson | Twitty | Gantt | Williams | 54.20 |
| 8 | High Point Academy | A | 57.17 | ||||
| 9 | Chesnee | A | Edmonds | Hickok | Barrs | Tilley | 57.66 |