| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | HUGHLEY, Jyron | Cardinal Newman |
22.47 | Louie Bing Invitational |
| 2 | ANTONUCCI, Peter | FAU High |
22.39 | Pine Crest Varsity Open |
| 3 | EMERSON, Jamarkus | Forest Hill |
22.34 | TFRRS 03/21/25 - 22.34 at Clyde Harris Invitational on 3/21/2025 |
| 4 | PAUL, Prince | Wellington |
22.27 | Cardinal Newman Invitational 2025 |
| 5 | EDWARD, Calbert | Pahokee |
22.29 | Glades Central Invite #1 2025 |
| 6 | AUGUSTIN, Presten | Dwyer |
22.37 | Cardinal Newman Invitational 2025 |
| 7 | CAMPBELL, Drew | Spanish River |
22.41 | Jeff Fossen Invitational 2025 |
| 8 | STINFORT, ArMuad | Glades Central |
22.49 | PBGHS Invitational 2025 |
| Lane | Athlete | Team | Seed | Note |
|---|---|---|---|---|
| 1 | WINFIELD, Michael | Benjamin School |
22.22 | Kings Academy Varsity 2 |
| 2 | RAY, Jerrmyll | Glades Central |
22.18 | Pahokee Andre Powell Invitational |
| 3 | HORNE, Tavius | Atlantic (Delray) |
21.83 | Spanish River Invitational 2025 |
| 4 | SANDERS, Zamarii | Cardinal Newman |
21.13 | 2025 The Ellis Elite 16 Track and Field Invitational |
| 5 | MILLER, Jackson | Cardinal Newman |
21.77 | Cardinal Newman Invitational 2025 |
| 6 | STEWART, Tristan | King's Academy |
21.94 | Calvary Christian FTL Varsity Invitational |
| 7 | GERALD, Kelsey | Santaluces |
22.19 | Glades Central Invite #1 2025 |
| 8 | TIMOTHEE, Jason | Atlantic (Delray) |
22.27 | Atlantic HS Invitational 2 |