| Lane | Team | Squad | Seed | Note | 
|---|---|---|---|---|
| 3 | Eastern Lebanon County | A | 4:31.19 | 19th Annual Bryn Mawr Running Co | 
| 4 | Lancaster Catholic | A | 4:25.10 | @LCHS v Annville-Cleona 5/5/2025 | 
| 5 | Northern Lebanon | A | 4:30.53 | Sterling Hoffman Track & Field I | 
| Lane | Team | Squad | Seed | Note | 
|---|---|---|---|---|
| 2 | Elizabethtown Area | A | 4:19.0h | |
| 3 | Manheim Central | A | 4:13.14 | Penn Relays Carnival Presented b | 
| 4 | Penn Manor | A | 4:10.89 | 17th Cy Fritz Open @ Millersvill | 
| 5 | Manheim Township | A | 4:11.2h | |
| 6 | Octorara | A | 4:18.90 | 21st Annual Unionville Invitatio | 
| 7 | Cocalico | A | 4:21.34 | 4/22 dual meet against Etown | 
| Lane | Team | Squad | Seed | Note | 
|---|---|---|---|---|
| 1 | Hempfield 03 | A | 4:09.67 | Penn Relays Carnival Presented b | 
| 2 | Garden Spot | A | 4:06.99 | 19th Annual Bryn Mawr Running Co | 
| 3 | Cedar Crest | A | 4:02.20 | Lebanon County Championships | 
| 4 | JP McCaskey | A | 3:58.1h | v. Manheim Township | 
| 5 | Conestoga Valley | A | 4:01.68 | 19th Annual Bryn Mawr Running Co | 
| 6 | Warwick | A | 4:06.2h | |
| 7 | Solanco | A | 4:08.77 | 17th Cy Fritz Open @ Millersvill | 
| 8 | Annville-Cleona | A | 4:10.07 | Lebanon County HS T&F Championsh |