| MR | Stan Morgan | 42.34 | Kent, Gilchrist, Kent, Day | Harrisburg | 2018 |
| Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note | |
|---|---|---|---|---|---|---|---|---|
| 1 | Chambersburg | A | Watson | Jones | Frey-Reyes | Harrison II | 42.09 | Verified |
| 2 | Carlisle | A | Crim | Smith | Mosley | Pretopapa | 42.71 | Unverified: CD vs. Carlisle vs. Mifflin |
| 3 | Columbia | A | 44.01 | Unverified: | ||||
| 4 | Mechanicsburg Area | A | 44.04 | Verified | ||||
| 5 | Cumberland Valley | A | Efeturi | Ekezie | Bramblett | Himmad | 44.24 | Unverified: |
| 6 | Cedar Cliff | A | Schriver | Crawford | Martin | Schriver | 44.50 | Verified |
| 7 | Waynesboro | A | Mobley | Williams | Royer | Hammond | 44.94 | Unverified: vs Shipp |
| 8 | Central Dauphin East | A | Jennings | Evans | Hardison | Porter | 45.18 | Verified |
| 9 | Lower Dauphin | A | Everett | Shradley | Sanders | Persing | 45.23 | Verified |
| 10 | Trinity 03 | A | 45.23 | Verified | ||||
| 11 | Red Land | A | Chippo | Lonkart | Ort | Walter | 45.64 | Unverified: Mechanicsburg |
| 12 | Boiling Springs | A | Fravel | Butler | Heller | Salviano | 45.80 | Verified |