| R | MAC Outdoor Champ | 3:52.96 | E. Slader, L. Weaver, E. Seeland, T. Wiederrecht | Messiah | 5/4/2019 |
| MAC Outdoor Overall | 3:50.11 | K. Fairchild, M. Fairchild, M. Fry, A. Viti | Misericordia | 2015 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Delaware Valley |
A | Blackmon | Mullen | Hastings | Joseph | NT | |
| 2 | Stevenson |
A | Wilson | Sabo | Gooch | Day | 4:34.72 | 2022 Messiah Multi/Invitational |
| 3 | Hood |
A | Mason | Heller | Castillo | Hancock | 4:33.45 | Towson Invitational 2022 |
| 4 | DeSales |
A | Dorsheimer | Klinger | Markwalter | Radcliffe | 4:17.15 | 2022 Messiah Multi/Invitational |
| 5 | A | Dainauski | Zambetti | Albright | O'Connor | 4:20.29 | Kings College Monarch Open | |
| 6 | A | McGarry | Stravinsky | Malleo | Pavlovich | 4:33.65 | Kings College Monarch Open | |
| 7 | Albright |
A | Holder | Daniels | Show | Gingrich | 4:39.26 | Muhlenberg Invitational |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | York (Pa.) |
A | Wagner | Mann | Skane | Bankert | 4:15.01 | Hopkins Loyola Invitational |
| 2 | Misericordia |
A | Hackenberg | Badillo | Allen | Rine | 4:06.61 | Misericordia Twilight |
| 3 | Lebanon Valley |
A | McCurdy | Good | Peiffer | Berkheimer | 4:03.63 | Widener Invitational |
| 4 | Stevens |
A | Meyer | Canciani | Dello Russo | Pinho | 3:59.61 | Vassar College April Invitational |
| 5 | Messiah |
A | Longshaw | Graybill | Vargas | Seeland | 4:01.05 | Danny Curran Invitational |
| 6 | Widener |
A | Ford | Holt | Sweely | Bernotas | 4:06.42 | Widener Invitational |
| 7 | Alvernia |
A | Schwarz | Philippe | Kavulak | Pirollo | 4:13.50 | Blue Jay Tune-Up |
| 8 | Eastern |
A | Peters | Wright | Shreffler | Ulaky | 4:15.68 | Kings College Monarch Open |