| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 2 | Montoursville Area | A | Pauling | Stone | Meyer | Saul | 4:32.54 |
| 3 | Fairfield Area | A | Strosnider | Nagy | Chesko | Dennison | 4:34.89 |
| 4 | Huntingdon Area | A | Fortney | Linn | Heffner | Delozier | 5:13.30 |
| 5 | Greenwood | A | Taylor | Tanner | Lyter | Brinser | 4:32.82 |
| 6 | Plymouth Whitemarsh | B | DNS |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 2 | Danville Area | A | 4:32.15 | ||||
| 3 | Cedar Cliff | A | Faircloth | Joy | LaFountain | Nugin | 4:29.50 |
| 4 | Eastern Lebanon County | A | 4:24.64 | ||||
| 5 | Milton Area | A | Bergey | Lopez | Murray | Walter | 4:24.75 |
| 6 | Shippensburg | A | Sydnor | Yeager | Kalp | Frontino | 4:31.14 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Bedford | A | 4:22.63 | ||||
| 2 | Hollidaysburg Area | A | Ali | Miller | Moyer | Waksmonski | 4:21.47 |
| 3 | Plymouth Whitemarsh | A | 4:20.24 | ||||
| 4 | Ephrata | A | Parsons | Baker | Schwartz | Long | 4:17.64 |
| 5 | Radnor | A | 4:19.78 | ||||
| 6 | Liberty | A | 4:21.24 | ||||
| 7 | Northern | A | Suzuki | Barrett | Engle | Lehman | 4:22.36 |
| 8 | Palmyra | A | Chapin | Miller | Newman | Simmons | 4:23.91 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Trinity (3) | A | Cloak | Shore | Crowell | Maury | 4:17.25 |
| 2 | South Western | A | 4:16.60 | ||||
| 3 | Mechanicsburg Area High School | A | Yameogo | England | Dillon | Lebo | 4:13.57 |
| 4 | Dallas | A | Basara | Filali | Fleschut | Kellar | 4:12.44 |
| 5 | State College Area High School | A | 4:12.59 | ||||
| 6 | Altoona Area | A | 4:15.32 | ||||
| 7 | Boiling Springs | A | Bush | Felix | Mundell | Chamberlin | 4:16.64 |
| 8 | Lake Lehman | A | O'Donnell | Raczkowski | Karlowicz | Keefe | 4:17.56 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Shikellamy | A | Koontz | Fausey | Keeley | Ronk | 4:11.49 |
| 2 | Lewisburg Area | A | Brazier | Ikeler | Blakeslee | Malone | 4:09.53 |
| 3 | Easton Area | A | Day | Emin | Vincent | Scalzo | 4:04.04 |
| 4 | Cumberland Valley | A | Robertson | Pines | Boardman | Ebersole | 3:59.95 |
| 5 | Susquehannock | A | Derkosh | Bartlett | Fisher | Fahringer | 4:03.80 |
| 6 | Upper Darby | A | 4:06.00 | ||||
| 7 | Selinsgrove | A | Molina-Shuman | Parise | Fry | Aument | 4:10.53 |
| 8 | Lower Dauphin | A | Swartz | Hollenbach | Korczynski | Gula | 4:12.24 |