| # | County | 42.25 | D Duffy, C Parker, A Iskander, T Maurer | Carmel | 5/13/2021 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 |
|---|---|---|---|---|---|---|
| 1 | Hamilton Heights | A | Crail | Chandler | Fleming | Shlater |
| 2 | Guerin Catholic | A | Moody | Cler | Macey | Horn |
| 3 | Noblesville | A | Bond | Donahoe | Collier | Wilson |
| 4 | Westfield | A | McCray | Terril | Gearhart | June |
| 5 | Hamilton Southeastern | A | Boyd | Tholen | Weston | Christopherson |
| 6 | Fishers | A | Rozzi | Spittler | Hall | Eloms |
| 7 | Carmel | A | Pack | Snarr | Ott | Rothenberger |