| # | Meet Recod | 1:03.58 | M Loftin, M Kemp, E Blackmore, A Elsbury | HSE | 2022 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 |
|---|---|---|---|---|---|---|
| 2 | Penn | A | Hernandez | Stevens | Bailey | Mullins |
| 3 | Center Grove | A | Payne | Hodges | Gubert | Clark |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 |
|---|---|---|---|---|---|---|
| 1 | Hamilton Southeastern | A | Reynolds | McMullen | Bullock | Smith |
| 2 | Warren Central | A | Smith | Smith | Jackson | Porch |
| 3 | Lawrence North | A | Dilosa | Ransom | Lax | Freeman |
| 4 | Ft. Wayne Northrop | A | Goldman | Tinsley | Greene | Moore |