| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 1 | SLEDGE, Paul | FR | Mulberry | 11.82 | FHSAA 2A District 10 (4/23/2022) |
| 2 | DYER, Sytrevion | SO | Tenoroc | 11.62 | FHSAA 2A District 10 (4/23/2022) |
| 3 | LOZADA, Anthony | JR | Oasis | 11.32 | FHSAA 2A District 12 (4/21/2022) |
| 4 | MCCLELLAN, Usir | SR | Clearwater Central Catholic | 11.23 | FHSAA 2A District 9 (4/28/2022) |
| 5 | EDWARDS, Ajani | SR | Jesuit (Tampa) | 11.26 | FHSAA 2A District 9 (4/28/2022) |
| 6 | EDWARDS, James | SR | Clewiston | 11.43 | FHSAA 2A District 12 (4/21/2022) |
| 7 | HARRIS, Khristian | SO | Discovery | 11.74 | FHSAA 2A District 10 (4/23/2022) |
| 8 | SMITH, Jordan | SO | Davenport | 11.95 | FHSAA 2A District 10 (4/23/2022) |
| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 1 | STARKS, LaDamien | SR | Hudson | 11.14 | FHSAA 2A District 9 (4/28/2022) |
| 2 | TERRY, Donovan | SO | Jesuit (Tampa) | 11.05 | FHSAA 2A District 9 (4/28/2022) |
| 3 | MOSS, Von | FR | Parrish | 10.99 | FHSAA 2A District 11 (4/19/2022) |
| 4 | MASON, Keveun | FR | Lake Placid | 10.90 | FHSAA 2A District 11 (4/19/2022) |
| 5 | SIMON, Rolant | JR | Hardee | 10.92 | FHSAA 2A District 11 (4/19/2022) |
| 6 | VITORITT, Parker | SO | Parrish | 11.02 | FHSAA 2A District 11 (4/19/2022) |
| 7 | POWELL, Lashawn | SR | Port Charlotte | 11.13 | FHSAA 2A District 12 (4/21/2022) |
| 8 | COBB, Chauncey | JR | Clewiston | 11.15 | FHSAA 2A District 12 (4/21/2022) |