| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 1 | GENISIO, Gavin | SO | Benton | 4:13.93 | |
| 2 | FALK, Nick | SR | Winnetka (New Trier) | 4:14.39 | 4:14.39 |
| 3 | MANNING, Aidan | SR | Verona Area | 4:15.87 | |
| 4 | WILSON, Micah | SR | St. Charles (East) | 4:17.39 | |
| 5 | BOSLEY, Owen | JR | Homestead | 4:18.03 | from indoors 2022 |
| 6 | SCHUMACHER, Michael | SR | Arlington Heights (St. Viato | 4:18.86 | |
| 7 | KLEIN, Jack | SR | Chicago (Lane) | 4:19.00 | DMR anchor at Arcadia |
| 8 | ATKINS, Michael | SR | Wheaton (W. Warrenville Sout | 4:19.14 | |
| 9 | HARDIMAN, Ryan | SR | Chicago (Latin) | 4:20.98 | 4:20.98 - Meet of Champs |
| 10 | STRAYER, Nicholas | SO | LaGrange (Lyons) | 4:21.67 | |
| 11 | PHILLIPS, Jake | SR | Chicago (Marist) | 4:21.78 | |
| 12 | NOREN, Luke | JR | Naperville (Central) | 4:21.86 | |
| 13 | GEE, Kevin | SR | Chicago (Mather) | 4:21.89 | Deerfield Invite 5/15/21 |
| 14 | REVORD, Colby | SR | Hinsdale (Central) | 4:22.21 | |
| 15 | HOFFMAN, Justin | SR | Kankakee Valley | 4:22.50 | |
| 16 | DANIEL, Zach | SR | Barrington | 4:22.57 | Top Times 3.26.22 |
| 17 | PUTZ, Manny | FR | Onalaska | 4:22.69 | |
| 18 | WARD, Griffin | SR | Middleton | 4:20.41 |