| Athlete | Team | Seed | |
|---|---|---|---|
| 1 | Alivia Cleveland | Fort Mill | 5:02.12 |
| 2 | Kendra Miles | Lexington | 5:05.22 |
| 3 | Abigail White | Chapin | 5:05.51 |
| 4 | Kennedy Roush | J.L. Mann | 5:11.40 |
| 5 | Madison Roush | J.L. Mann | 5:14.42 |
| 6 | Sofie Kurzawa | J.L. Mann | 5:17.49 |
| 7 | Lydia Metz | Lexington | 5:18.34 |
| 8 | Mia Royall | Nation Ford | 5:19.61 |
| 9 | Caroline Timms | T.L. Hanna | 5:21.17 |
| 10 | Avery Bender | Carolina Forest | 5:26.90 |
| 11 | Kelsey McGuire | Fort Mill | 5:28.45 |
| 12 | Reagan Cooke | Mauldin | 5:28.92 |
| 13 | Avery Moriarty | Fort Mill | 5:29.15 |
| 14 | Taylor Battle | Nation Ford | 5:34.04 |
| 15 | Brittany Mobley-Meulman | Rock Hill | 5:34.24 |
| 16 | Elizabeth Rogers | Riverside | 5:35.06 |