| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | OJR | A | DNS | ||||
| 2 | Germantown Friends School | A | Guida, Gigi | Macdonald, Anna | Marcelis, Annika | Rovinsky, Isabel | 4:24.00 |
| 3 | Henderson | B | 4:25.08 | ||||
| 4 | Henderson | C | 4:26.10 | ||||
| 5 | Haverford Township HS | A | DNS | ||||
| 6 | Garnet Valley | B | 4:30.00 | ||||
| 7 | Padua Academy | A | Cleary, Anna | Holowka, Jackie | Mazzeo, Clare | Speed, Mackenzie | 4:35.00 |
| 8 | Spring Ford | A | DNS |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | D-West | A | Zednik, Kennedy | Wallace, Lindsay | Cichon, Ashley | DiOttavio, Lauren | 4:18.24 |
| 2 | D-East | A | Urbanski, Siena | Korsunsky, Rebecca | Ohara, Emily | Stevenson, Bry | 4:13.00 |
| 3 | D-West | B | Schreiber, Sarah | Mucha, Grace | Stanfield, Chloe | Flannery, Reagan | 4:12.00 |
| 4 | Upper Darby | A | 4:06.24 | ||||
| 5 | Garnet Valley | A | 4:08.00 | ||||
| 6 | Henderson | A | 4:10.08 | ||||
| 7 | Tatnall | A | Farina, Mia | Teklits, Lainey | Woods, Kimmi | Howard, Vanessa | 4:15.00 |
| 8 | Upper Darby | B | 4:18.24 |