Section 1 of 2
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 3 | Ft. Zumwalt North High School | A | Serna | Davis | Gatewood | Maier | 4:35.06 |
| 4 | Troy Buchanan High School | A | Robinson | Hunolt | Brown | Wortmann | 4:31.91 |
| 5 | Ft. Zumwalt West High School | A | Pridemore | Maupin | Madrid | St. Jean | 4:33.65 |
| 6 | Mehlville High School | A | Escamilla | Kimberlin | Roberts | Dang | DNS |
Section 2 of 2
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | St. Charles West High School | A | Malinee | Myers | Zeier | Jackson | 4:29.78 |
| 2 | Northwest (Cedar Hill) High Scho | A | 4:27.21 | ||||
| 3 | Francis Howell High School | A | Sidwell | Ihrig | Thornton | Williams | 4:16.55 |
| 4 | Parkway Central High School | A | Elbert | Lee | Parsons | Okpara | 4:15.32 |
| 5 | Farmington High School | A | Cassimatis | Eaves | Gerstner | Earley | 4:16.42 |
| 6 | Christian High School | A | Wagner | Corwin | Swinigan | Schroer | 4:25.81 |
| 7 | Ft. Zumwalt East High School | A | Antwi | Karr | Bergland | Rowold | 4:29.27 |
| 8 | Timberland High School | A | Craft | Goodman | Wall | Busateri | 4:30.79 |
