Section 1 of 2
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 3 | St. Charles West High School | A | House | Shivers | Malinee | Zeier | 2:12.54 |
| 4 | Mehlville High School | A | Pesselato | Nasufovic | Crittendon | Abdijanovic | 2:06.74 |
| 5 | Francis Howell North High School | A | Gamble | Harmon | Anderson | Hamilton | 2:10.32 |
Section 2 of 2
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Ft. Zumwalt North High School | A | Ramadan | Wischmann | Bampton | Serna | DNF |
| 2 | Northwest (Cedar Hill) High Scho | A | 1:55.05 | ||||
| 3 | Troy Buchanan High School | A | Robinson | Hunolt | Brown | Starkey | 1:53.00 |
| 4 | Parkway Central High School | A | Parsons | Elbert | Jackson | Okpara | 1:48.00 |
| 5 | Francis Howell High School | A | Sidwell | Williams | Thornton | Williams | 1:50.94 |
| 6 | Timberland High School | A | Hildebrand | Goodman | Utley | Lewis | 1:54.02 |
| 7 | Ft. Zumwalt West High School | A | Rowland | Pridemore | St. Jean | Onuoha | 1:57.63 |
| 8 | Christian High School | A | Malone | Phillips | Kassebaum | Cunningham | 2:00.51 |
