| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 1 | GREGORY, Elijah | JR | Centralia (Christ Our Rock Lutheran) | 4:45.15 | |
| 2 | WEBER, Max | FR | Edwardsville (Metro-East Lutheran) | 4:49.60 | |
| 3 | JACOB, Noah | FR | Maryville (M. Christian) | 4:56.44 | |
| 4 | SCHMIDT, Liam | FR | Glen Carbon (Father McGivney) | 4:57.36 | |
| 5 | BOEVING, Liam | SO | Glen Carbon (Father McGivney) | 5:01.64 | |
| 6 | KOCH, Zerek | SO | Centralia (Christ Our Rock Lutheran) | 5:18.00 | |
| 7 | BROEKEMEIER, Adam | JR | Edwardsville (Metro-East Lutheran) | 5:34.11 |