Event Note:
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Liberty | A | Dorciak, Nicol | Jobe, Maliah | Khaw, Rachel | Romeo, Bonnie | 4:15.80 | |
| 2 | Sandy | A | Thompson, Abigail | Salveter, Marley | Eri, Tana | Thompson, Madeline | 4:16.13 | |
| 3 | Wilsonville | A | Greene, Jillian | Burke, Kristen | Cerdan, Bethany | Johnson, Kristine | 4:15.10 | |
| 4 | La Salle Prep | A | Minsker, Sarah | Griese, Sophie | Herder, Emma | Holenstein, Talya | 4:01.36 | |
| 5 | St Helens | A | Shriver, Lillianna | Estep, Sophie | Hanna, Josie | Hora, Gabby | 4:10.30 | |
| 6 | Hillsboro | A | Ellsworth, Maddy | Miyama, Bri | Raabe, Juliet | Stearns, Cheyenne | 4:15.28 | |
| 7 | Putnam | A | Martinez, Sarah | O'Halloran, Dainelle | Johnson, Taylor | Herbert, Abigail | 4:35.60 |