| AQ | D4 State AQ | 4:28.60 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Beal City | A | Trommater | Bowerman | Pastotnik | Hubble | 4:48.77 | |
| 2 | Merrill | A | Colpean | Acker | Hickey | Pappas | 4:41.47 | |
| 3 | Mt. Pleasant Sacred Heart | A | Theisen | Rose | Predum | Wills | 4:22.85 | |
| 4 | Fowler | A | Wieber | Thelen | Thelen | Schafer | 4:16.27 | |
| 5 | St. Charles | A | Payne | Mose | Zelinko | Hafner | 4:16.70 | |
| 6 | Saginaw Michigan Lutheran Se | A | Munson | Wallace | Wakefield | Frederick | 4:28.93 | |
| 7 | Montabella | A | Lumbert | Clay | Shelley | Curtiss | 4:43.43 | |
| 8 | Vestaburg | A | Seeley | Carver | Oakley | Stouten | 5:09.55 |