| R | Meet Rec. | 3:53.29 | Alma | 2017 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 2 | Hemlock | A | Launstein | Lewis | Locanto-Massa | Mundell | 4:45.83 | |
| 3 | Lakeview | A | Moldondo | Lupien | Allen | Rosenburger | 4:27.00 | |
| 4 | West Int. Mt. Pleasant | A | House | Benjamin | Green | Walton | 4:16.75 | |
| 5 | Birch Run | A | Wood | West | DiBerardino | Gielda | 4:23.80 | |
| 6 | TS Nurnberger | A | Hassell | Allen | Wonch | Contreras | 4:36.58 | |
| 7 | Fulton | A | Michael | Brown | Lin | Wang Burley | 4:52.22 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Mt. Pleasant Sacred Heart | A | Egan | Liu | Reynolds | Morrison | DNS | |
| 2 | Shepherd | A | Krafft | Haag | Flegel | Willoughby | 4:06.19 | |
| 3 | Ithaca | A | Sheler II | Paradise | Huyck | Merchant | 4:04.65 | |
| 4 | Freeland | A | Lynch | Monroe | Koehler | Moeller | 4:03.00 | |
| 5 | Beal City | A | Latham | Gross | Funnell | Butkovich | 4:04.44 | |
| 6 | Fowler | A | Thelen | Spitzley | Fedewa | Thelen | 4:05.10 | |
| 7 | Swan Valley | A | Booth | Murphy | Habina | Charboneau | 4:06.54 | |
| 8 | Chesaning | A | Maynard | Lapine | Guymer | Lopez | 4:14.00 |