Hand Times
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 3 | Immaculata |
B | Morris | Haas | Sprock | Hays | 4:40.00 | |
| 4 | Immaculata |
A | Darlak | Gillin | Humphries | Kipers | 4:37.80 | Bow Tie Invitational |
| 5 | Albright |
A | Gingrich | Holder | Show | Crosby | DNS |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Elizabethtown |
A | Weaver | Wiley | Webber | Kennedy | 4:30.00 | |
| 2 | A | Lieb | Heller | Fertig | Huber | 4:29.26 | York College Twilight Meet | |
| 3 | Franklin & Marshall |
B | Sanchez | Fieberg | O'Connell | Salerno | 4:14.00 | |
| 4 | Alvernia |
A | Herzog | Schoener | Angstadt | Schwarz | 4:12.90 | 2021 MAC Outdoor Track & Field Championships |
| 5 | Franklin & Marshall |
A | Dzenutis | Danyi | Greene | Kline | 4:13.00 | |
| 6 | Dickinson |
A | Matala | Kratovil-Lavelle | Berman | Clarke | 4:20.00 | |
| 7 | McDaniel |
A | Short | Dupre | O'Neill | Siebenhaar | 4:30.00 | |
| 8 | Elizabethtown |
B | Georgieff | Guelcher | Bosak | Lysek-Hagy | 4:31.00 |